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Case Report
Online Published: 05 Nov 2018
 


Metformin Overdose and Severe Lactic Acidosis

Qandeel Nawadat, Awais Khalid, Ajaz Waheed.


Abstract
Metformin belongs to biguanide group of oral hypoglycemic drugs which is used in combina- tion with other oral hypoglycemic agents in patients suffering from type II diabetes melitus. It is used with caution in patients with renal impairment and liver dysfunction as it is excreted through renal and hepatic routes. Metformin toxicity may be intentional or accidental and although the actual toxic mechanism remains unclear, it is usually associated with severe lactic acidosis. This case report is about a young female who intentionally ingested 30g of metformin, and focuses on presentation, emergency resuscitative measures, investigations, and definite management plan.
This case was reported to show that the Metformin toxicity is usually not reported and that if we institute early dialysis and reverse the high anion gap acidosis, the chances of survival can significantly improve.

Key words: Metformin toxicity, lactic acidosis, hemodialysis


 
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How to Cite this Article
Pubmed Style

Nawadat Q, Khalid A, Waheed A. Metformin Overdose and Severe Lactic Acidosis. SAJEM. 2018; 1(1): 30-32.

Web Style

Nawadat Q, Khalid A, Waheed A. Metformin Overdose and Severe Lactic Acidosis. https://www.sajem.org/?mno=302643537 [Access: June 22, 2026].

AMA (American Medical Association) Style

Nawadat Q, Khalid A, Waheed A. Metformin Overdose and Severe Lactic Acidosis. SAJEM. 2018; 1(1): 30-32.


Vancouver/ICMJE Style

Nawadat Q, Khalid A, Waheed A. Metformin Overdose and Severe Lactic Acidosis. SAJEM. (2018), [cited June 22, 2026]; 1(1): 30-32.


Harvard Style

Nawadat, Q., Khalid, . A. & Waheed, . A. (2018) Metformin Overdose and Severe Lactic Acidosis. SAJEM, 1 (1), 30-32.


Turabian Style

Nawadat, Qandeel, Awais Khalid, and Ajaz Waheed. 2018. Metformin Overdose and Severe Lactic Acidosis. South Asian Journal of Emergency Medicine, 1 (1), 30-32.


Chicago Style

Nawadat, Qandeel, Awais Khalid, and Ajaz Waheed. "Metformin Overdose and Severe Lactic Acidosis." South Asian Journal of Emergency Medicine 1 (2018), 30-32.


MLA (The Modern Language Association) Style

Nawadat, Qandeel, Awais Khalid, and Ajaz Waheed. "Metformin Overdose and Severe Lactic Acidosis." South Asian Journal of Emergency Medicine 1.1 (2018), 30-32. Print.


APA (American Psychological Association) Style

Nawadat, Q., Khalid, . A. & Waheed, . A. (2018) Metformin Overdose and Severe Lactic Acidosis. South Asian Journal of Emergency Medicine, 1 (1), 30-32.


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