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Case Report
Online Published: 13 Apr 2019
 


Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy

Muhammad Usman Ghani.


Abstract
We are reporting a case of intentional polypharmacy with beta blockers, calcium channel blockers, alpha adrenergic blockers and centrally acting antihypertensive agents in a young male with HCM. This unique presentation resulted in shock which didn't respond to all known interventions including intralipid. The patient finally responded to HIET and Vasopressin and after adrenaline was tapered and finally stopped. We feel early initiation of pure alpha agonist like vasopressin or phenylephrine could have been more successful in this scenario of hypotension and outflow obstruction.

In our literature search we came across a case report of combined B blocker/calcium channel blocker and amiodarone toxicity in a patient with HCM which responded well to intralipid. However, to our knowledge this is the first case report of life threatening overdose of B blocker, calcium channel blocker, alpha blocker and centrally acting antihypertensives in a patient with HCM.

Key words: Vasogenic shock, antihypertensives, toxicology, Hypertrophic cardiomyopathy, HIET


 
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How to Cite this Article
Pubmed Style

Muhammad Usman Ghani|. Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy. SAJEM. 2019; 2(1): 40-42. doi:10.5455/sajem.020106

Web Style

Muhammad Usman Ghani|. Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy. https://www.sajem.org/?mno=8573 [Access: June 27, 2026]. doi:10.5455/sajem.020106

AMA (American Medical Association) Style

Muhammad Usman Ghani|. Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy. SAJEM. 2019; 2(1): 40-42. doi:10.5455/sajem.020106


Vancouver/ICMJE Style

Muhammad Usman Ghani|. Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy. SAJEM. (2019), [cited June 27, 2026]; 2(1): 40-42. doi:10.5455/sajem.020106


Harvard Style

Muhammad Usman Ghani| (2019) Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy. SAJEM, 2 (1), 40-42. doi:10.5455/sajem.020106


Turabian Style

Muhammad Usman Ghani|. 2019. Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy. South Asian Journal of Emergency Medicine, 2 (1), 40-42. doi:10.5455/sajem.020106


Chicago Style

Muhammad Usman Ghani|. "Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy." South Asian Journal of Emergency Medicine 2 (2019), 40-42. doi:10.5455/sajem.020106


MLA (The Modern Language Association) Style

Muhammad Usman Ghani|. "Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy." South Asian Journal of Emergency Medicine 2.1 (2019), 40-42. Print. doi:10.5455/sajem.020106


APA (American Psychological Association) Style

Muhammad Usman Ghani| (2019) Vasogenic Shock Secondary to an Intentional Overdose of Multiple Antihypertensives in a patient with Hypertrophic Cardiomyopathy. South Asian Journal of Emergency Medicine, 2 (1), 40-42. doi:10.5455/sajem.020106


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